研究室紹介

Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice.

Hiroki Ishikawa, Ryuichi Nagashima, Yoshihiro Kuno, Hiraku Sasaki, Chikara Kohda, Masayuki Iyoda.
Diabetes, metabolic syndrome and obesity : targets and therapy, 16 :2855-2864 (2023)

doi: 10.2147/DMSO.S428190

The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells.

Amano H, Eshima K, Ito Y, Nakamura M, Kitasato H, Ogawa F, Hosono K, Iwabuchi K, Uematsu S, Akira S, Narumiya S, Majima M..
Cardiovascular Research, 119 (5) :1218-1233 (2023)

doi: 10.1093/cvr/cvac137

HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages.

Ryuichi Nagashima, Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Masayuki Iyoda.
Scientific reports, 13 (1) :1867 (2023)

doi: 10.1038/s41598-023-29161-3

Intravenous immunoglobulin preparations attenuate lysolecithin-induced peripheral demyelination in mice and comprise anti-large myelin protein zero antibody

Setoguchi, Y., Hayashi, A., Kawada, A., Ibusuki, A., Yanaoka, D., Saito, R., Ishibashi, T., Takimoto, H., Yamaguchi, Y., Ohtaki, H., Baba, H..
Proc Jpn Acad Ser B Phys Biol Sci, 99 (2) :48-60 (2023)
https://www.ncbi.nlm.nih.gov/pubmed/36775342

Oral supplementation of a cell preparation of Enterococcus faecalis strain EC-12 stimulates superoxide dismutase production in the livers of healthy and arthritis-induced mice

Tsukahara, T., Makioka-Itaya, Y., Takimoto, H., Ijichi, T..
J Clin Biochem Nutr, 72 (1) :39-45 (2023)
https://www.ncbi.nlm.nih.gov/pubmed/36777079

Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration.

Mishima K, Okabe YT, Mizuno M, Ohno K, Kitoh H, Imagama S..
Scientific Reports, 12 (1) :20550 (2022)
https://pubmed.ncbi.nlm.nih.gov/36446942/

doi: 10.1038/s41598-022-25184-4.

IL-33 attenuates renal fibrosis via group2 innate lymphoid cells.

Ryuichi Nagashima, Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Masayuki Iyoda.
Cytokine, 157 :155963 (2022)

doi: 10.1016/j.cyto.2022.155963.

Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 prevent influenza virus infection and attenuate secondary bacterial infection risk.

Hiroki Ishikawa, Yoshihiro Kuno, Chikara Kohda, Hiraku Sasaki, Ryuichi Nagashima, Masayuki Iyoda.
Letters in applied microbiology, 74 (5) :632-639 (2022)

doi: 10.1111/lam.13649

The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis.

Ryuichi Nagashima, Masayuki Iyoda.
Frontiers in immunology, 12 :688647 (2021)

doi: 10.3389/fimmu.2021.688647

Efficient immunogenic peptide antigen delivery to dendritic cells using an ESCRT-mediated extracellular vesicle formation method.

Sakika Kimura, Koki Maeda, Ryuichi Nagashima, Koya Miura, Masashi Arakawa, Hirotaka Ebina, Nobuyuki Tanaka, Eiji Morita.
Vaccine, 39 (22) :2976-2982 (2021)

doi: 10.1016/j.vaccine.2021.04.021.

Natural killer cell group 7 sequence in cytotoxic cells optimizes exocytosis of lytic granules essential for the Perforin-dependent, but not FasL-dependent cytolytic pathway.

Morikawa Y, Murakami M, Kondo H, Nemoto N, Iwabuchi K, Eshima K*..
ImmunoHorizons, 5 (4) :234-345 (2021)

doi: 10.4049/immunohorizons.2100029

Biological characterization of adipose-derived regenerative cells used for the treatment of stress urinary incontinence.

Okabe YT, Shimizu S, Suetake Y, Matsui-Hirai H, Hasegawa S, Takanari K, Toriyama K, Kamei Y, Yamamoto T, Mizuno M, Gotoh M..
International Journal of Urology, 28 (1) :115-124 (2021)
https://pubmed.ncbi.nlm.nih.gov/33289131/

doi: 10.1111/iju.14408.

NF-κB-inducing kinase contributes to normal development of cortical thymic epithelial cells: its possible role in shaping a proper T-cell repertoire.

Eshima K, Misawa K, Ohashi C, Noma H, Iwabuchi K..
Immunology, 160 (2) :198-208 (2020)

doi: 10.1111/imm.13186

Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells.

Makoto Kubo, Ryuichi Nagashima, Mitsue Kurihara, Fumitaka Kawakami, Tatsunori Maekawa, Koji Eshima, Etsuro Ohta, Hirotomo Kato, Fumiya Obata.
International journal of molecular sciences?, 21 (5) :1890 (2020)

doi: 10.3390/ijms21051890.

A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats.

Kitase Y, Sato Y, Ueda K, Suzuki T, Mikrogeorgiou A, Sugiyama Y, Matsubara K, Tsukagoshi Okabe Y, Shimizu S, Hirata H, Yukawa H, Baba Y, Tsuji M, Takahashi Y, Yamamoto A, Hayakawa M..
Stem Cells and Development, 29 (2) :63-74 (2020)
https://doi.org/10.1089/scd.2019.0221

doi.org/10.1089/scd.2019.0221

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.

Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Tsukagoshi Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M.
Nature communications, 10 (1) :4262 (2019)

doi.org/10.1038/s41467-019-12282-7

Invasion of human microvascular endothelial cells by Mycobacterium leprae through Mce1A protein

Idris, I., Abdurrahman, A. H., Fatulrachman,, Aftitah, V. B., Fadlitha, V. B., Sato, N., Fujimura, T., Takimoto, H..
J Dermatol, 46 (10) :853-858 (2019)
https://www.ncbi.nlm.nih.gov/pubmed/31432529

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response.

Ryuichi Nagashima, Hitomi Kosai, Masahiro Masuo, Keiko Izumiyama, Taketo Noshikawaji, Motoko Morimoto, Satoru Kumaki, Yasunari Miyazaki, Hozumi Motohashi, Masayuki Yamamoto, Nobuyuki Tanaka.
Journal of immunology, 202 (5) :1331-1339 (2019)

doi: 10.4049/jimmunol.1801180.

The unique tropism of Mycobacterium leprae to the nasal epithelial cells can be explained by the mammalian cell entry protein 1A

Fadlitha, V. B., Yamamoto, F., Idris, I., Dahlan, H., Sato, N., Aftitah, V. B., Febriyanda, A., Fujimura, T., Takimoto, H..
PLoS Negl Trop Dis, 13 (3) :e0006704 (2019)
https://www.ncbi.nlm.nih.gov/pubmed/30835734

Potent Inhibitory Effects of Quercetin on Inflammatory Responses of Collagen-Induced Arthritis in Mice

Kawaguchi, K., Kaneko, M., Miyake, R., Takimoto, H., Kumazawa, Y..
Endocr Metab Immune Disord Drug Targets, 19 (3) :308-315 (2019)
https://www.ncbi.nlm.nih.gov/pubmed/30727927

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.

Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M..
Journal of Hepatology, 69 (1) :110-120 (2018)

doi: 10.1016/j.jhep.2018.02.009

Modification of lipid A structure and activity by the introduction of palmitoyltransferase gene to the acyltransferase-knockout mutant of Escherichia coli

Sugawara, T., Onoue, S., Takimoto, H., Kawahara, K..
Microbiol Immunol, 62 (8) :497-506 (2018)
https://www.ncbi.nlm.nih.gov/pubmed/29932223

Role of T-bet, the master regulator of Th1 cells, in the cytotoxicity of murine CD4+ T cells.

Eshima K, Misawa K, Ohashi C, Iwabuchi K..
Microbiology and Immunology, 65 (5) :348-356 (2018)

doi: 10.1111/1348-0421.12586

Euglena gracilis Z and its carbohydrate storage substance relieve arthritis symptoms by modulating Th17 immunity

Suzuki, K., Nakashima, A., Igarashi, M., Saito, K., Konno, M., Yamazaki, N., Takimoto, H..
PLoS One, 13 (2) :e0191462 (2018)
https://www.ncbi.nlm.nih.gov/pubmed/29389956

Oral administration of Euglena gracilis Z and its carbohydrate storage substance provides survival protection against influenza virus infection in mice

Nakashima, A., Suzuki, K., Asayama, Y., Konno, M., Saito, K., Yamazaki, N., Takimoto, H..
Biochem Biophys Res Commun, 494 (1月2日) :379-383 (2017)
https://www.ncbi.nlm.nih.gov/pubmed/28974421

Morphometrical and Morphological Alterations of Human Leukocytes Exposed to 1.8 GHz Electromagnetic Radiations: In Vitro Protective Effects Induced by Polyphenols

Biagi, P. F., Boffola, S., Stefanelli, R., Schiavulli, L., Ligonzo, T., Casamassima, G., Pappagallo, M. T., Kawaguchi, K., Takimoto, H., Kumazawa, Y., Fontana, S., Laforgia, F., Russo, M. A., Magrone, T., Jirillo, E..
Endocr Metab Immune Disord Drug Targets, 16 (3) :189-196 (2016)
https://www.ncbi.nlm.nih.gov/pubmed/27697072

BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils.

Kojo K, Ito Y, Eshima K, Nishizawa N, Ohkubo H, Yokomizo T, Shimizu T, Watanabe M, Majima M..
Scientific Reports, 6 :29650 (2016)

doi: 10.1038/srep29650

Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses.

Makoto Kubo, Ryuichi Nagashima, Etsuro Ohta, Tatsunori Maekawa, Yumiko Isobe, Mitsue Kurihara, Koji Eshima, Kazuya Iwabuchi, Toshikuni Sasaoka, Sadahiro Azuma, Heather L Melrose, Matthew J Farrer, Fumiya Obata.
Journal of neuroimmunology, 292 :1月8日 (2016)

doi: 10.1016/j.jneuroim.2016.01.005.

Analysis of possible suppression mechanisms for HIV-1 replication in CD4+ T cells co-cultured with alloantigen-stimulated CD8+ T cells.

Ryuichi Nagashima, Fumiya Obata, Makoto Kubo.
The Kitasato Medical Journal, 46 (1) :32-39 (2016)

Differential dependence on nuclear factor-κB-inducing kinase among natural killer T-cell subsets in their development.

Noma H, Eshima K*, Satoh M, Iwabuchi K.
Immunology, 146 (1) :88-99 (2015)

doi: 10.1111/imm.12484.

Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions.

Amano H, Ito Y, Eshima K, Kato S, Ogawa F, Hosono K, Oba K, Tamaki H, Sakagami H, Shibuya M, Narumiya S, Majima M..
Cardiovascular Research, 107 (4) :509-521 (2015)

doi: 10.1093/cvr/cvv139

Prostanoid induces premetastatic niche in regional lymph nodes.

Ogawa F*, Amano H*, Eshima K*, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiya S, Majima M..
Journal of Clinical Investigation, 124 (11) :4882-4894 (2014)

doi: 10.1172/JCI73530

Allo-antigen stimulated CD8+ T-cells suppress NF-κB and Ets-1 DNA binding activity, and inhibit phosphorylated NF-κB p65 nuclear localization in CD4+ T-cells.

Ryuichi Nagashima, Fumitaka Kawakami, Shinichiro Takahashi, Fumiya Obata, Makoto Kubo.
Viral immunology, 27 (6) :305-315 (2014)

doi: 10.1089/vim.2013.0113.

Biodistribution of locally or systemically transplanted osteoblast-like cells.

Okabe Y T, Kondo T, Mishima K, Hayase Y, Kato K, Mizuno M, Ishiguro N and Kitoh H.
Bone and Joint Research, 3 :76-81 (2014)
https://pubmed.ncbi.nlm.nih.gov/24652780/

doi: 10.1302/2046-3758.33.2000257.

Significant Involvement of NF-κB-inducing Kinase in Proper Differentiation of αβ and γδ T cells.

Eshima K, Okabe M, Kajiura S, Noma H, Shinohara N, Iwabuchi K..
Immunology, 141 (2) :222-232 (2014)

doi: 10.1111/imm.12186

Potential use of dietary natural products, especially polyphenols, for improving type-1 allergic symptoms

Kumazawa, Y., Takimoto, H., Matsumoto, T., Kawaguchi, K..
Curr Pharm Des, 20 (6) :857-63 (2013)
https://www.ncbi.nlm.nih.gov/pubmed/23701564

Immunomodulating and anti-allergic effects of Negroamaro and Koshu Vitis vinifera fermented grape marc (FGM)

Marzulli, Giuseppe, Magrone, Thea, Vonghia, Luisa, Kaneko, Masahiro, Takimoto, Hiroaki, Kumazawa, Yoshio, Jirillo, Emilio.
Curr Pharm Des, 20 (6) :864-8 (2013)
https://www.ncbi.nlm.nih.gov/pubmed/23701568