研究室紹介

Human intestinal organoid-derived PDGFRα?+?mesenchymal stroma enables proliferation and maintenance of LGR4?+?epithelial stem cells

Chen JL, Horiuchi S, Kuramochi S, Kawasaki T, Kawasumi H, Akiyama S, Arai T, Morinaga K, Kimura T, Kiyono T, Akutsu H, Ishida S, Umezawa A.
Stem Cell Research & Therapy, 15 :16 (2024)
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-023-03629-5

Stem cell challenges and opportunities

Ite K, Toyoda M, Akiyama S, Enosawa S, Yoshioka S, Yukitake T, Yamazaki-Inoue M, Tatsumi K, Akutsu H, Nishina H, Kimura T, Otani N, Nakazawa A, Fukuda A, Kasahara M, Umezawa A.
Progress in Molecular Biology and Translational Science, 199 :379-395 (2023) https://www.sciencedirect.com/science/article/abs/pii/S1877117323000637?via%3Dihub

Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells

Akiyama S, Saku N, Miyata S, Ite K, Nonaka H, Toyoda M, Kamiya A, Kiyono T, Kimura T, Kasahara M, Umezawa A.
Progress in Molecular Biology and Translational Science, 199 :155-178 (2023)
https://www.sciencedirect.com/science/article/abs/pii/S1877117323000546

AKTシグナルによる細胞初期化促進の分子機構

関田　洋一, 木村　透.
生化学　みにれびゅう, 95 (1) :66-71 (2023)
https://seikagaku.jbsoc.or.jp/10.14952/SEIKAGAKU.2023.950066/index.html

Spatiotemporal changes of tissue glycans depending on localization in cardiac aging

Itakura Y, Hasegawa Y, Kikkawa Y, Murakami Y, Sugiura K, Nagai-Okatani C, Sasaki N, Umemura M, Takahashi Y, Kimura T, Kuno A, Ishiwata T, and Toyoda M.
Regenerative Therapy, 22 (1) :68-78 (2023)
https://www.sciencedirect.com/science/article/pii/S2352320422001316?via%3Dihub

Genetic variation in the Y chromosome and sex-biased DNA methylation in somatic cells in the mouse

Batdorj E, AlOgayil N, Galvez JH, Zhuang QK, Bauermeister K, Nagata K, Kimura T, Ward M, Taketo T, Bourque G, and Naumova AK.
Mammalian Genome, 34 (1) :44-55 (2023)
https://link.springer.com/article/10.1007/s00335-022-09970-z

Switching defective/sucrose non-fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and Meiosin activation in female germline

Ito T, Ohta M, Osada A, Nishiyama A, Ishiguro KI, Tamura T, Sekita Y, and Kimura T.
Genes to Cells, 28 (1) :15-28 (2023)
https://onlinelibrary.wiley.com/doi/full/10.1111/gtc.12990

Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain

Kojima S*, Shiochi N*, Sato K, Yamaura M, Ito T, Yamamura N, Goto N, Odamoto M, Kobayashi S, Kimura T, and Sekita Y.
Nucleic Acids Research, 50 (9) :5080-5094 (2022)
https://academic.oup.com/nar/advance-article-abstract/doi/10.1093/nar/gkac344/6584436

*The first two authors are contributed equally to this work.

Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture

Akiyama S, Saku N, Miyata S, Ite K, Toyoda M, Kimura T, Kuroda M, Nakazawa A, Kasahara M, Nonaka H, Kamiya A, Kiyono T, Kobayshi T, Murakami Y, and Umezawa A.
Stem Cell Research & Therapy, 13 :104 (2022)
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02776-5

Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury

Miyata S, Saku N, Akiyama S, Javaregowda PK, Ite K, Takashima N, Toyoda M, Yura K, Kimura T, Nishina H, Nakazawa A, Kasahara M, Nonaka H, Kiyono T, and Umezawa A.
Stem Cell Research & Therapy, 13 :6 (2022)
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02680-4

The SWI/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline

Ito T, Osada A, Ohta M, Yokota K, Nishiyama A, Niikura Y, Tamura T, Sekita Y, and Kimura T.
Scientific Reports, 11 :24074 (2021)
https://www.nature.com/articles/s41598-021-03538-8

AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation

Sekita Y, Sugiura Y, Matsumoto A, Kawasaki Y, Konno R, Akasaka K, Shimizu M, Ito T, Sugiyama E, Yamazaki T, Kanai E, Nakamura T, Suematsu M, Ishino F, Kodera Y, Kohda T, and Kimura T.
Stem Cell Research & Therapy, 12 (1) :510 (2021)
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02578-1

Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells

Tsuneishi R, Saku N, Miyata S, Akiyama S, Javaregowda PK, Ite K, Takashima N, Toyoda M, Kimura T, Kuroda M, Nakazawa A, Kasahara M, Nonaka H, Kamiya A, Kiyono T, Yamauchi J, and Umezawa A.
Scientific Reports, 11 :11381 (2021)
https://www.nature.com/articles/s41598-021-90708-3

A RUNX-CBFbeta–driven enhancer directs the Irf8 dose-dependent lineage choice between dendritic cells and monocytes

Murakami K, Sasaki H, Nishiyama A, Kawase W, Kurotaki D, Nakabayashi J, Kanzaki S, Sekita Y, Nakajima H, Ozato K, Kimura T, and Tamura T.
Nature Immunology, 22 (3) :301-311 (2021)
https://www.nature.com/articles/s41590-021-00871-y

Five multicopy gene family genes expressed during the maternal-to-zygotic transition are not essential for mouse development

Wakabayashi M, Tamura S, Kanzaki S, Kosugi M, Yoshimura Y, Ito T, Nagata K, Sato K, Takada S, Sekita Y, and Kimura T.
Biochem. Biophys. Res. Commun., 534 (4) :752-757 (2021)
https://www.sciencedirect.com/science/article/pii/S0006291X20320477

Immortalization of human zone I hepatocytes with CDK4R24C, cyclin D1, and hTERT for cytochrome P450 induction testing

Nishiwaki M, Toyoda M, Ohishi Y, Ishida S, Horiuchi S, Makino-Itou H, Kimura T, Ohno SI, Ohkura T, Enosawa S, Akutsu H, Nakazawa A, Kasahara M, Kiyono T, and Umezawa A.
Scientific Reports, 10 :17503 (2020)
https://www.nature.com/articles/s41598-020-73992-3

Involvement of Nlrp9a/b/c in mouse preimplantation development

Kanzaki S, Tamura S, Ito T, Wakabayashi M, Saito K, Kato S, Ohta Y, Sekita Y, and Kimura T.
Reproduction, 160 (2) :181-191 (2020)
https://rep.bioscientifica.com/view/journals/rep/160/2/REP-19-0516.xml

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice

Kosugi M, Otani M, Kikkawa Y, Itakura Y, Sakai K, Ito T, Toyoda M, Sekita Y, and Kimura T.
Biochem. Biophys. Res. Commun., 525 (1) :100-106 (2020)
https://www.sciencedirect.com/science/article/pii/S0006291X20303119

Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background

Sakai K, Ito C, Wakabayashi M, Kanzaki S, Ito T, Takada S, Toshimori K, Sekita Y, and Kimura T.
Scientific Reports., 9 :13757 (2019)
https://www.nature.com/articles/s41598-019-50318-6

Reprogramming of germ cells into pluripotency

Sekita Y, Nakamura T, and Kimura T.
World J. Stem Cells., 8 (8) :251-259 (2016)
http://www.wjgnet.com/1948-0210/full/v8/i8/251.htm

Dppa3 controls chromocenter formation through regulation of Daxx expression in 2-cell embryos

Arakawa T, Nakatani T, Oda M, Kimura Y, Sekita Y, Kimura T, Nakamura T, and Nakano T.
Biochem. Biophys. Res. Commun., 466 (1) :60-65 (2015)
http://www.sciencedirect.com/science/article/pii/S0006291X15304988

Stella preserves maternal chromosome integrity by inhibiting 5hmC-dependent gH2AX accumulation

Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, Sekita Y, Arakawa T, Nakamura T, and Nakano T.
EMBO Reports, 16 (5) :582-589 (2015)
http://embor.embopress.org/content/16/5/582.long

Dppa3 expression is critical for generation of fully-reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting

Xu X, Smorag L, Nakamura T, Kimura T, Dressel R, Fitzner A, Tan X, Linke M, Zechner U, Engel W, and Pantakani DVK.
Nature Communications, 6 :6008 (2015)
http://www.nature.com/ncomms/2015/150123/ncomms7008/full/ncomms7008.html

Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds

Kimura T*, Kaga Y, Sekita Y, Fujikawa K, Nakatani T, Odamoto M, Funaki S, Ikawa M, Abe K, and Nakano T.
Stem Cells, 33 (1) :45-55 (2015)
http://onlinelibrary.wiley.com/doi/10.1002/stem.1838/abstract

*corresponding author

The majority of early primordial germ cells acquire pluripotency by Akt activation.

Matsui Y, Takehara A, Tokitake Y, Ikeda M, Obara Y, Morita-Fujimura Y, Kimura T, and Nakano T.
Development, 141 (23) :4457-4467 (2014)
http://dev.biologists.org/content/141/23/4457.full

Induction of primordial germ cell-like cells from mouse embryonic stem cells by ERK signal inhibition

Kimura T*, Kaga Y, Ohta H, Odamoto M, Sekita Y, Li K, Yamano N, Fujikawa K, Isotani A, Sasaki N, Toyoda M, Hayashi K, Okabe M, Shinohara T, Saitou M, and Nakano T.
Stem Cells, 32 (10) :2668-2678 (2014)
http://onlinelibrary.wiley.com/doi/10.1002/stem.1781/abstract

*corresponding author

始原生殖細胞から多能性幹細胞への誘導

木村　透.
産科と婦人科　特集「幹細胞と生殖医学」, 81 (3) :323-327 (2014)

GPAT2, a mitochondrial acyltransferase, in piRNA biogenesis in germline stem cells.

Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamaura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, and Nakano T.
RNA, 19 (6) :803-810 (2013)

Effects of Dppa3 on DNA methylation dynamics during primordial germ cell development.

Nakashima H, Kimura T, Kaga Y, Nakatani T, Seki Y, Nakamura T, and Nakano T.
Biol Reprod, 88 (5) :125, 1-9 (2013)

哺乳類の生殖細胞における分化多能性の誘導

木村　透.
実験医学　増刊「再生医療を実現化する幹細胞のメディカルサイエンス」, 30 (10) :1579-1583 (2012)

Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.

Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, himokawa I, Akira S, Kubo Y, Mak TW, and Matsuyama T.
Proc Natl Acad Sci USA, 108 (46) :18766-18771 (2011)

Induction of pluripotency in primordial germ cells.

Kimura T, and Nakano T.
Histol Histopatho, 26 (5) :643-650 (2011)

始原生殖細胞から多能性幹細胞への初期化機構

木村　透.
医学のあゆみ「次世代iPS医療」, 239 (14) :1283-1288 (2011)

Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation.

Yamano N, Kimura T*, Watanabe-Kushima S, Shinohara T, and Nakano T*.
Biochem. Biophys Res Commun, 392 (3) :311-316 (2010)

*corresponding authors

MVH in piRNA processing and gene silencing of retrotransposons.

Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Kimura T, Nakatsuji N, Noce T, Sasaki H, and Nakano T.
Genes Dev, 24 (9) :887-892 (2010)

Associations between PIWI Proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells.

Kojima K, Kuramochi-Miyagawa S, Chuma S, Tanaka T, Nakatsuji N, Kimura T, and Nakano T.
Genes Cells, 14 (10) :1155-1165 (2009)

Regulation of stem cell systems by PI3K/Akt signaling.

Kimura T and Nakano T.
Regulatory Networks in Stem Cells; Rajasekhar VK and Vemuri M. Eds.,  :309-317 (2009)

 

Effects of Akt signaling on nuclear reprogramming.

Nakamura T, Inoue K, Ogawa S, Umehara H, Ogonuki N, Miki H, Kimura T, Ogura A, and Nakano T.
Genes Cells, 13 (12) :1269-1277 (2008)

PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation.

Kita K, Kimura T*, Nakamura N, Yoshikawa H, and Nakano T*.
Genes Cells, 13 (8) :839-850 (2008)

*corresponding authors

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.

Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M , Asada N, Kojima K, Yamaguchi Y, Ijiri T, Hata K, Li E, Matsuda Y, Kimura T, Okabe M, Sakaki Y, Sasaki H, and Nakano T.
Genes Dev, 22 (7) :908-917 (2008)

AKT signaling promotes derivation of embryonic germ cells form primordial germ cells.

Kimura T, Tomooka M, Yamano N, Murayama K, Matoba S, Umehara H, Kanai Y, and Nakano T.
Development, 135 (5) :869-879 (2008)

Efficient derivation of embryonic stem cells by inhibition of glycogen synthase kinase 3.

Umehara H, Kimura T, Ohtsuka S, Nakamura T, Kitajima K, Ikawa M, Okabe M, Niwa H, and Nakano T.
Stem Cells, 25 (11) :2705 – 2711 (2007)

Akt mediates self-renewal division of mouse spermatogonial stem cells.

Lee J, Shinohara-Kanatsu M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Kimura T, Nakano T, Ogura A, and Shinohara T.
Development, 134 (10) :1853-1859 (2007)

Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors.

Murayama K, Kimura T*, Tarutani M, Tomooka M, Hayashi R, Okabe M, Nishida K, Itami S, Katayama I, and Nakano T*.
Oncogene, 26 (33) :4882-4888 (2007)

*corresponding authors

PGC7/Stella protects against DNA demethylation in early embryogenesis.

Nakamura T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, Sekimoto T, Ikawa M, Yoneda Y, Okabe M, Tanaka S, Shiota K, and Nakano T.
Nature Cell Biol, 9 (1) :64-71 (2007)

Stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression.

Kimura T, Nakamura T, Murayama K, Umehara H, Yamano N, Watanabe S, Taketo MM, and Nakano T.
Dev Biol, 300 (1) :545-553 (2006)

Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells.

Watanabe S, Umehara H, Murayama K, Okabe M, Kimura T*, and Nakano T*.
Oncogene, 25 (19) :2697-2707 (2006)

*corresponding authors

Differential effects of GATA-1 on proliferation and differentiation of erythroid lineage cells.

Zheng J, Kitajima K, Sakai E, Kimura T, Minegishi N, Yamamoto M, and Nakano T.
Blood, 107 (2) :520-527 (2006)

Testicular teratomas: back to pluripotent stem cells.

Kimura T, Murayama K, Nakamura T, Watanabe S, Umehara H, Tomooka M, and Nakano T.
Developmental Biology of Neoplastic Growth; Progress in Molecular and Subcellular Biology Series, Macieira-Coelho A. Eds.,  :133-150 (2005)

 

Stage-specific expression of mouse germ cell-less-1 (mGCL-1) and multiple deformation during mgcl-1 deficient spermatogenesis leading to reduced fertility.

Maekawa M, Ito C, Toyama Y, Suzuki-Toyota F, Kimura T, Nakano T, and Toshimori K.
Arch Histol Cytol, 67 :335-347 (2004)

Mili, a mammalian member of piwifamily gene, is essential for spermatogenesis.

Kuramochi-Miyagawa S, Kimura T, Ijiri T, Isobe T,  Asada N, Fujita Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y, and Nakano T.
Development, 131 :839-849 (2004)

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production.

Kimura T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW, and Nakano T.
Development, 130 :1691-1700 (2003)

Mouse germ cell-less as an essential component for nuclear integrity.

Kimura T, Ito C, Watanabe S, Takahashi T, Ikawa M, Yomogida K, Fujita Y, Ikeuchi M, Asada N, Matsumiya K, Okuyama A, Okabe M, Toshimori K, and Nakano T.
Mol Cell. Biol, 23 :1304-1315 (2003)

Cadherin-mediated cell interaction regulates germ cell determination in mice.

Okamura D, Kimura T, Nakano T, and Matsui Y.
Development, 130 :6423-6430 (2003)

Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.

Masuhara M, Nagao K, Nishikawa M, Kimura T, and Nakano T.
Biochem Biophys Res Commun, 308 :927-932 (2003)

Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells.

Sato M, Kimura T, Kurokawa K, Fujita Y, Abe K, Masuhara M, Yasunaga T, Ryo A, Yamamoto M, and Nakano T.
Mech Dev, 113 :91-94 (2002)

Two mouse piwi-related genes: miwi and mili.

Kuramochi-Miyagawa S, Kimura T, Yomogida K, Kuroiwa A, Tadokoro Y, Fujita Y, Sato M, Matsuda Y, and Nakano T.
Mech Dev, 108 :121-133 (2001)

Alteration of cell adhesion and cell cycle properties of ES cells by an inducible dominant interfering Myb mutant.

Iwai N, Kitajima K, Sakai K, Kimura T, and Nakano T.
Oncogene, 20 :1425-1434 (2001)

Unique monoclonal antibody recognizing the third extracellular loop of the human CXCR4 induces lymphocyte agglutination and enhances human immunodeficiency virus type-I-mediated syncytium formation and productive infection.

Tanaka R, Yoshida A, Murakami T, Baba E, Lichtenfeld J, Omori T, Kimura T, Tsurutani N, Fujii N, Wang Z-X, Pepier SC, Yamamoto N, and Tanaka Y.
J Virol, 75 :11534-11543 (2001)

Proliferation and cell death of embryonic primitive erythrocytes.

Kimura T, Sonoda Y, Iwai N, Satoh M, Yamaguchi-Tsukio M, Izui T, Suda M, Sasaki K, and Nakano T.
Exp Hematol, 28 :635-641 (2000)

Antisense phosphorothioate oligonucleotides targeted to the human chemokine receptor CXCR4.

Kusunoki A, Miyano-Kurosaki N, Kimura T, Takai K, Yamamoto N, Gushima H, and Takaku H.
Nucleosides Nucleotides Nucleic Acids., 19 :1709-1719 (2000)

Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression.

Fukushi M, Dixon J, Kimura T*, Tsurutani N, Dixon MJ, and Yamamoto N.
FEBS Letters, 442 :83-88 (1999)

*corresponding author

Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells.

Kimura T*, Yomogida K, Iwai N, Kato Y, and Nakano T.
Biochem Biophys Res Commun, 262 :223-230 (1999)

*corresponding author

bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation.

Motoyama N, Kimura T, Takahashi T, Watanabe T, and Nakano T.
J Exp Med, 189 :1691-1698 (1999)

Determinant in human immunodeficiency virus type 1 for efficient replication under cytokine-induced CD4+ T-helper 1 (Th1)- and Th2-type conditions.

Suzuki Y, Koyanagi Y, Tanaka Y, Murakami T, Misawa N, Maeda N, Kimura T, Shida H, Hoxie JA, O'Brien WA, and Yamamoto N.
J Virol, 73 :316-324 (1999)

Activation of the transcription factor ISGF3 by interferon-gamma.

Matsumoto M, Tanaka N, Harada H, Kimura T, Yokochi T, Kitagawa M, Schindler C, and Taniguchi T.
Biol Chem, 380 :699-703 (1999)

Antisense oligodeoxynucleotide complementary to CXCR4 mRNA block replication of HIV-1 in COS cells.

Kusunoki A, Wada A, Kurosaki N, Kimura T, Takai K, Yamamoto N, and Takaku H.
Nucleosides Nucleotides, 18 :1705-1708 (1999)

The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.

Penninger JM, Sirard C, Mittruer H-W, Chidgey A, Kozieradzki I, Nghiem M, Hakem A, Kimura T, Timms E, Boyd R, Taniguchi T, Matsuyama T, and Mak TW.
Immunity, 7 :243-254 (1997)

Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T Cells in vitro and in vivo

Kawano Y, Tanaka Y, Misawa N, Tanaka R, Kira J-I, Kimura T, Fukushi M, Sano K, Goto T, Nakai M, Kobayashi T, Yamamoto N, and Koyanagi Y.
J Virol., 71 :8456-8566 (1997)

 

Essential and non-redundant roles of p48 (ISGF3gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.

Kimura T, Kadokawa Y, Harada H, Matsumoto M, Sato M, Kashiwazaki Y, Tarutani M, Tan RS-P, Takasugi T, Matsuyama T, Mak TW, Noguchi S, and Taniguchi T.
Genes Cells, 1 :115-124 (1996)

Regulation of IFN-alpha/beta genes; Evidence for dual function of the transcription factor complex, ISGF3 in the production and action of IFN-alpha/beta.

Harada H, Matsumoto M, Sato M, Kashiwazaki Y, Kimura T, Kitagawa M, Yokochi T, Tan RS-P, Takasugi T, Kadokawa Y, Schindler C, Schreiber RD, Noguchi S, and Taniguchi T.
Genes Cells, 1 :995-1005 (1996)

Involvement of the IRF-1 transcription factor in antiviral responses to interferons.

Kimura T*, Nakayama K*, Penninger J, Kitagawa M, Harada H, Matsuyama T, Tanaka N, Kamijo R, Vil?ek J, Mak TW, and Taniguchi T.
Science, 264 :1921-1924 (1994)

*The first two corresponding authors are contributed equally to this work

Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano D, Shapiro D, Le J, Koh SI, Kimura T, Green SJ, Mak TW, Taniguchi T, and Vil?ek J.
Science, 263 :1612-1615 (1994)

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

Tanaka N, Ishihara M, Kitagawa M, Harada H, Kimura T, Matsuyama T, Lamphier MS, Aizawa S, Mak TW, and Taniguchi T.
Cell, 77 :829-839 (1994)

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN induction and aberrant lymphocyte development.

Matsuyama T*, Kimura T*, Kitagawa M, Pfeffer K, Kawakami T, Watanabe N, Kündig TM, Amakawa R, Kishihara K, Wakeham A, Potter J, Furlonger CL, Narendran A, Suzuki H, Ohashi PS, Paige CJ, Taniguchi T, and Mak TW.
Cell, 75 :83-97 (1993)

*The first two authors are contributed equally to this work.

The amino acid sequence of a flavodoxin from the eukaryotic red alga Chondrus crispas.

Wakabayashi S, Kimura T, Fukuyama K, Matsubara H, and Rogers LJ.
Biochem J, 163 :981-984 (1989)