ロゴ
大学施設

RESEARCH

研究室紹介

生命物理学

キーワード:#質量分析 #X線?中性子回折 #タンパク質

物理的な観点で生命?生物のシステムの解明を目指す

本講座では、質量分析技術とバイオインフォマティクスの融合や、X線?クライオ電子顕微鏡を用いて、生物システムの担い手であるタンパク質間ネットワークの解析と、各タンパク質の機能解明を目指し研究を進めています。

業績

Fibrocyte Phenotype of ENTPD1+CD55+ Cells and Its Association with Pain in Osteoarthritic Synovium

Tsuchiya M., Ohashi Y., Fukushima K., Okuda Y., Suto A., Matsui T.Kodera Y., Sato M., Tsukada A., Inoue G., Takaso M., Uchida K.
Int. J. Mol. Sci., 25(7): 4085, (2024)
https://doi.org/10.3390/ijms25074085

CD39+CD55? Fb Subset Exhibits Myofibroblast-Like Phenotype and Is Associated with Pain in Osteoarthritis of the Knee

Tsuchiya M., Ohashi Y., Kodera Y., Satoh M., Matsui T., Fukushima K., Iwase D., Aikawa J., Mukai M., Inoue G., Takaso M., Uchida K.
Biomedicines, 11(11): 3047, (2023)
https://doi.org/10.3390/biomedicines11113047

Interaction between membranous EBP50 and myosin 9 as a favorable prognostic factor in ovarian clear cell carcinoma.

Nakagawa M., Matsumoto T., Yokoi A., Hashimura M., Oguri Y., Konno R., Ishibashi Y., Ito T., Ohhigata K., Harada Y., Fukagawa N., Kodera Y., Saegusa M.
Mol. Oncol., (2023)
https://doi.org/10.1002/1878-0261.13503

 

Nucleobindin-2 Mediates Transforming Growth Factor-β1 -Driven Phenotypes in Zinc Finger E-Box Binding Homeobox 1-High Uterine Carcinosarcoma.

Kobayashi Y., Yokoi A., Hashimura M., Oguri Y., Konno R., Matsumoto T., Tochimoto M., Nakagawa M., Ishibashi Y., Ito T., Ohhigata K., Harada Y., Fukagawa N., Kodera Y., Saegusa M..
Am. J. Pathol.193 (8) :1116-1128 (2023)
https://doi.org/10.1016/j.ajpath.2023.04.011

 

Synthesis of epitope-targeting nanobody based on native protein-protein interactions for FtsZ filamentation suppressor.

Nakazawa H., Katsuki T., Matsui T., Tsugita A., Yokoyama T., Ito T., Kawada S., Tanaka Y., Umetsu M.
Biotechnol. J., :e2300039 (2023)
https://doi.org/10.1002/biot.202300039

 

Assessment of inconsistencies in the solvent-accessible surfaces of proteins between crystal structures and solution structures observed by LC-MS

Matsui T.,Kojitani E.,Takasawa T., Suto A., Tamari A., Watanabe G., Kodera Y.
Biochem. Biophys. Res. Commun.640 :97-104 (2022)
https://doi.org/10.1016/j.bbrc.2022.11.094

 

A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation.

Watari H., Kageyama H., Masubuchi N., Nakajima H., Onodera K., Focia P.J., Oshiro T., Matsui T., Kodera Y., Ogawa T., Yokoyama T., Hirayama M., Hori K., Freymann D.M., Imai M., Komatsu N., Araki M., Tanaka Y., Sakai R.
Nature Commun.13 (1) :7262 (2022)
https://doi.org/10.1038/s41467-022-34921-2

 

Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase.

Hamdy S.A., Kodama T., Nakashima Y., Han X., Matsui T., Morita H..
J. Nat. Med.76 (4) :873-879 (2022)
https://doi.org/10.1007/s11418-022-01635-0

 

Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43.

Sato T., Oda K., Sakai S., Kato R., Yamamori S., Itakura M., Kodera Y., Nishizawa M., Sasaoka T., Onodera O., Yokoyama M..
Sci. Rep.12 (1) :14923 (2022)
https://doi.org/10.1038/s41598-022-19153-0

 

ANGT_HUMAN[448-462], an Anorexigenic Peptide Identified Using Plasma Peptidomics.

Sasaki S., ObaK, Kodera Y., Itakura M., Shichiri M.
J. Endocr. Soc.6 (7) :bvac082 (2022)
https://doi.org/10.1210/jendso/bvac082

 

The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK

Tsugita A.,Uehara S., Matsui T., Yokoyama T., Ostash I., Deneka M., Yalamanchili S., Bennett C.S., Tanaka Y., Ostash B.
FEBS J.289 (19) :6038-6057 (2022)
https://doi.org/10.1111/febs.16460

 

Chimeric mutants of staphylococcal hemolysin, which act as both one-component and two-component hemolysin, created by grafting the stem domain.

Ghanem N., Kanagami N., Matsui T., Takeda K., Kaneko J., Shiraishi Y., Choe C.A., Uchikubo-Kamo T., Shirouzu M., Hashimoto T., Ogawa T., Matsuura T., Po-Ssu H., Yokoyama T., Tanaka Y.
FEBS J.289 (12) :3505-3520 (2022)
https://doi.org/10.1111/febs.16354

 

A novel peptide identified from visceral ganglia induces oocyte maturation, spermatozoa active motility, and spawning in the pen shell Atrinapectinata.

Funayama S., Matsumoto T., Kodera Y., Awaji M.
Biochem. Biophys. Res. Commun.598 :9-14 (2022)
https://doi.org/10.1016/j.bbrc.2022.02.006

 

LC-MS peak assignment based on unanimous selection by six machine learning algorithms.

Ito H., Matsui T., Konno R., Itakura M., Kodera Y.
Sci. Rep.11 (1) :23411 (2021)
https://doi.org/10.1038/s41598-021-02899-4

 

AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation.

Sekita Y., Sugiura Y., Matsumoto A., Kawasaki Y., Akasaka K., Konno R., Shimizu M., Ito T., Sugiyama E., Yamazaki T., Kanai E., Nakamura T., Suematsu M., Ishino F., Kodera Y., Kohda T., Kimura T..
Stem Cell Res. Ther.12 (1) :510 (2021)
https://doi.org/10.1186/s13287-021-02578-1

 

Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma.

Matsumoto T., Yoki A., Konno R., Oguri Y., Hashimura M., Tochimoto M., Nakagawa M., Jiang Z., Ishibashi Y., Ito T., Kodera Y., Saegusa M.
Carcinogenesis42 (9) :1162-1170 (2021)
https://doi.org/10.1093/carcin/bgab070

 

GIP_HUMAN[22-51] is a new proatherogenic peptide identified by native plasma peptidomics.

Masaki T., Kodera Y., Terasaki M., Fujimoto K., Hirano T., Shichiri M.
Sci. Rep.11 (1) :14470 (2021)
https://doi.org/10.1038/s41598-021-93862-w

 

Circulating prorenin: its molecular forms and plasma concentrations

Fujimoto K., Kawamura S., Bando S., Kamata Y., Kodera Y., Shichiri M.
Hypertens. Res.44 (6) :674-684 (2021)
https://doi.org/10.1038/s41440-020-00610-0

 

A highly efficient method for extracting peptides from a single mouse hypothalamus

Nakagawa Y., Matsui T., Konno R., Kawashima Y., Sato T., Itakura M., Kodera Y..
Biochem. Biophys. Res. Commun.548 :155-160 (2021)
https://doi.org/10.1016/j.bbrc.2021.02.041

 

Highly accurate and precise quantification strategy using stable isotope dimethyl labeling coupled with GeLC-MS/MS

Konno R., Matsui T., Ito H., Kawashima Y., Itakura M., Kodera Y..
Biochem. Biophys. Res. Commun.550 :37-42 (2021)
https://doi.org/10.1016/j.bbrc.2021.02.101

 

Suprabasin-derived bioactive peptides identified by plasma peptidomics

Taguchi T., Kodera Y., Oba K., Saito T., Nakagawa Y., Kawashima Y., Shichiri M.
Sci. Rep.11 (1) :1047 (2021)
https://doi.org/10.1038/s41598-020-79353-4